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KMID : 0357919860200040399
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Korean Journal of Pathology
1986 Volume.20 No. 4 p.399 ~ p.412
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Effects of the Reticuloendothelial System on the Formation of Nonspecific Reactive Hepatitis in Rats
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Abstract
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This study was designed to evaluate the effects of altered reticuloendothelial function
on the formation of nospecific reactive hepatitis in rats.
Increased activity of reticuloendothelial system was evoked by methylcellulose treatment
(20 ㎎/100 g). Partial depression of reticuloendothelial system was induced by
splenectomy.
Experimental nospecific reactive hepatitis was made by Escherichia coli treatment,
artificial stomach perforation and ileum ligation, respectively.
The nonspecific reactive hepatitis thus made evaluated by liver function tests such as
AST ALT and alkaline phosphatase.
Histological and electron microscopical observation were also done.
The results obtained were as follows:
1. Functional and histological changes of nospecific reactive hepatitis deffered with the
disign employed.
2. Partial reduction of reticuloendothelial activity by splenectomy didn't influence the
serverity of nonspecific reactive hepatitis.
3. Increase of reticuloendothelial activity by methyl cellulose treatments reduced the
severity of nonspecific reactive hepatitis lesion developed by E. coli treatment and
stomach perforation, both functionally and morphologically.
4. Changes of nonspecific reactive hepatitis by ileum ligations, however, were
aggrevated by increased recticuloendothelial activity.
These results showed the divers effect of altered reticuloendothelial function on the
degree of nospecific reactive hepatitis according to the employed experimental designs.
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KEYWORD
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